Combinatorial Chemistry
Combinatorial chemistry, by accelerating the process of chemical synthesis, is having a profound effect on all branches of chemistry, but especially on drug discovery. This informative text explains the origins of combinatorial chemistry and puts the many diverse library methods into context. It explains why some techniques are generally applicable and others are for specialists only. It also focuses on the renaissance of solid phase chemistry and describes the range of available reactions. This is the first single author book in this important, growing field and it describes the beneficial impact of combinatorial chemistry, especially for the discovery and optimisation of biologically active molecules. This concise and comprehensive overview of combinatorial techniques is an essential text for final year undergraduates, postgraduates, academics and industrialists in chemistry, bio-orgainc chemistry, medicinal chemistry and drug discovery. It provides an accessible introduction to the area for those new to these methods and a valuable reference text to those experienced in this field.Solution. phase. library. synthesis. 1. Introduction Much of this book has so far described the synthesis of combinatorial libraries on solid phase. ... automated processes has in general restricted the use of solution chemistry to short synthetic sequences using reliable chemistry. ... Parallel solution synthesis Manual or automated approaches can be used for the parallel preparation of tens to hundreds ofanbsp;...
| Title | : | Combinatorial Chemistry |
| Author | : | Nicholas K. Terrett |
| Publisher | : | Oxford University Press on Demand - 1998 |
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